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Conquering childhood leukemia and regenerating T-cell immunity through collaboration and innovation

 

 

ABOUT US

We are a close-knit group of hard working scientists at the University of Michigan Medical School who are dedicated to studying the genes and pathways that drive hematopoietic regeneration and malignancy.

OUR VISION

Notch signaling controls developmentally important activities across many diverse tissues and drives T-cell commitment of stem cells at the expense of self-renewal, raising barriers for targeting this pathway to treat Notch-dependent cancers and restoring T-cell development after cytoreductive therapies. Our vision is that we can circumvent these barriers by controling Notch functions at the chromatin level through context-dependent Notch cofactors. For each cofactor, we investigate their normal roles in T-cell progenitor biology and their pathological roles in T-cell leukemia in order to fully understand how these cofactors might be manipulated in order to treat Notch-dependent cancers safely and regenerate Notch-dependent thymic stem cells after chemotherapy or bone marrow transplantion.

OUR RESEARCH INTERESTS
  • T-cell leukemogenesis and propagation

  • Combinatorial control of oncogenic enhancers

  • Murine and human models of leukemogenesis

  • T-cell regeneration after cytoreductive therapies like chemotherapy and bone marrow transplantation

  • Transcriptional regulation of early T-cell development

  • Murine and human models of thymopoiesis

  • Transcriptional genomics

  • ​Proteomic analysis of transcriptional complexes

  • Drug development

OUR SUPPORT
Mark Chiang laboratory
Mark Chiang laboratory
Mark Chiang laboratory
Mark Chiang laboratory
Mark Chiang laboratory
Mark Chiang laboratory
Mark Chiang laboratory
Mark Chiang laboratory
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Mark Chiang laboratory
Mark Chiang laboratory
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